Spaceflight accelerates the symptoms of aging in astronaut bodies by inducing genomic instability, mitochondrial dysfunction, and increased inflammation. This is the first study to comprehensively examine biomarkers and pathways associated with spaceflight and terrestrial aging, frailty, and sarcopenia. Main Findings: Spaceflight induced notable changes in gene expression patterns related to frailty and muscle loss indicative of a frailty-like condition. Exposure to the space environment leads to changes related to inflammation, muscle wasting, and other age-related features observed in both mice and humans. Parallels between spaceflight and the aging process may…
