Observing anything and everything within the human brain, no matter how large or small, while it is fully intact has been an out-of-reach dream of neuroscience for decades. But in a new study in Science, an MIT-based team describes a technology pipeline that enabled them to finely process, richly label, and sharply image full hemispheres of the brains of two donors — one with Alzheimer’s disease and one without — at high resolution and speed.“We performed holistic imaging of human brain tissues at multiple resolutions, from single synapses to whole brain…
